Innovative Methodology Partial nephrectomy as a model for uremic cardiomyopathy in the mouse
نویسندگان
چکیده
David J. Kennedy, Jihad Elkareh, Amjad Shidyak, Anna P. Shapiro, Sleiman Smaili, Krishna Mutgi, Shalini Gupta, Jiang Tian, Eric Morgan, Samer Khouri, Christopher J. Cooper, Sankaridrug M. Periyasamy, Zijian Xie, Deepak Malhotra, Olga V. Fedorova, Alexei Y. Bagrov, and Joseph I. Shapiro Departments of Medicine and Pharmacology, University of Toledo College of Medicine, Toledo, Ohio; and Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, Maryland
منابع مشابه
Partial nephrectomy as a model for uremic cardiomyopathy in the mouse.
Because of the plethora of genetic manipulations available in the mouse, we performed a partial nephrectomy in the mouse and examined whether the phenotypical features of uremic cardiomyopathy described in humans and rats were also present in the murine model. A 5/6 nephrectomy was performed using a combination of electrocautory to decrease renal mass on the left kidney and right surgical nephr...
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Gender difference has been suggested as a risk factor for developing cardiovascular and renal diseases in humans and experimental animals. As a major sex hormone, progesterone was reported to compete with cardiotonic steroid binding to Na/K-ATPase. Our previous publication demonstrated that cardiotonic steroids (e.g., marinobufagenin) play an important role in the development of experimental ur...
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We have previously reported that the sodium potassium adenosine triphosphatase (Na/K-ATPase) can effect the amplification of reactive oxygen species. In this study, we examined whether attenuation of oxidant stress by antagonism of Na/K-ATPase oxidant amplification might ameliorate experimental uremic cardiomyopathy induced by partial nephrectomy (PNx). PNx induced the development of cardiac mo...
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Uremic cardiomyopathy is responsible for high morbidity and mortality rates among patients with chronic kidney disease (CKD), but the underlying mechanisms contributing to this complex phenotype are incompletely understood. Myocardial deformation analyses (ventricular strain) of patients with mild CKD have recently been reported to predict adverse clinical outcome. We aimed to determine if earl...
متن کاملCentral role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy.
Patients with chronic renal failure develop a "uremic" cardiomyopathy characterized by diastolic dysfunction, cardiac hypertrophy, and systemic oxidant stress. Patients with chronic renal failure are also known to have increases in the circulating concentrations of the cardiotonic steroid marinobufagenin (MBG). On this background, we hypothesized that elevations in circulating MBG may be involv...
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